INTERNATIONAL WORKSHOP ON CANCER SYSTEMS BIOLOGY
Shenzhen · DragonStar · Young & Expert Forum · International Symposium
As research in cancer and cerebrovascular diseases enters a new era of precision, multi-omics, and interdisciplinary integration, a premier academic gathering of the world's leading minds is set to take place in Shenzhen. From December 2–7, 2025, the 14th International Workshop on Cancer Systems Biology (ICSB 2025), alongside the DragonStar Program Series, will be held in the city.
This year’s conference expands its scope to include Cerebrovascular Systems Biology, establishing a unified platform for global scholars to share groundbreaking discoveries, technological advances, and clinical translation efforts in both cancer and cerebrovascular research. Together, we aim to foster a high-level international forum dedicated to advancing precision medicine.
| Date | Module | Highlights |
|---|---|---|
| Dec 2-4 | DragonStar Program Course | Led by Prof. Ying Xu, this course delves into core methodologies in tumor and cerebrovascular systems biology—including multi-omics analysis and AI modeling—to equip young researchers and graduate students with a solid theoretical and technical foundation. |
| Dec 5 | Young & Expert Forum on Systems Biology | A dynamic platform where young scholars present innovative work and established experts share insights and provide targeted feedback, fostering intergenerational dialogue and sparking new collaborations. |
| Dec 6-7 | International Symposium | Featuring 19 keynote presentations by globally leading scientists, this session explores cutting-edge topics such as tumor metabolism, 3D genomics, and cerebrovascular regulation, offering visionary perspectives on future trends. |
Professor, School of Life Sciences, Tsinghua University
Integrates RNA biology with AI to decode post-transcriptional regulation, spatial omics landscapes and tumor development.
Focus: RNA regulation · Spatial omics · AI
Professor, Shenzhen Institute of Advanced Technology
Builds single-cell/space multi-omics technologies to probe “neural–immune–infection” systems with Nature Genetics and Neuron papers.
Focus: Space multi-omics · Neuro-immunology
Research Professor, Navy Medical University
Leads the National Liver Cancer Science Center signaling lab, dissecting HCC initiation and therapy resistance.
Focus: Liver cancer · Signal transduction
Researcher, SIAT, Chinese Academy of Sciences
Combines genomics, lineage tracing and mathematical modeling to map early tumor evolution from polyclonal to monoclonal states.
Focus: Tumor evolution · Computational biology
Researcher, SIAT, Chinese Academy of Sciences
Creates comprehensive human immune atlases that integrate computational biology, molecular profiling, clinical cohorts and animal models.
Focus: Immune atlas · Computational immunology
Director, Precision Therapy Dept., Changhai Hospital
Develops multi-omics + AI pipelines for urologic cancers, enabling prostate cancer subtyping and liquid biopsy.
Focus: Urologic oncology · Precision medicine
Professor, Harbin Medical University
Biomedical and tumor immuno-informatics expert with Nature Reviews Genetics and Science Advances papers; listed among the global top 2% scientists.
Focus: Immuno-informatics · Translational analytics
Researcher, China National Center for Bioinformation
Dissects non-coding RNA and RNA modification regulation while co-developing sequencing algorithms and curated databases.
Focus: Non-coding RNA · Epigenetics
Researcher, Renji Hospital, SJTU
Targets tumor immune microenvironments by reprogramming macrophages and endothelial cells to boost T-cell therapies.
Focus: Immune microenvironment · Immunotherapy
Researcher, Institute of Agricultural Genomics, CAAS
Builds AI algorithms for multi-dimensional health and nutrition data to decode chronic disease risk, with cover stories in Nature and Nature Computational Science.
Focus: Chronic disease analytics · AI for health data
Professor, Fudan University
Heads the Intelligent Life Science Center and pioneers AI-driven drug discovery with 150+ publications.
Focus: AI for therapeutics
Professor, Fudan University
Computational biologist focused on multi-omics analytics and national precision-medicine programs.
Focus: Computational multi-omics
Professor, Wuhan University
Explores essential genes for synthetic biology and drug discovery, publishing in NAR and Briefings in Bioinformatics.
Focus: Essential genes · Synthetic biology
Professor, Jilin University
Develops interpretable, cross-modal AI systems for biological cognition with 100+ papers in Nat. Commun., IEEE TKDE, KDD, etc.
Focus: Interpretable AI · Complex systems
Researcher, School of AI, Jilin University
Specializes in causal learning and AI-for-biomedicine, authoring influential monographs and leading NSFC projects.
Focus: Causal inference · AI + Biomed
Postdoctoral Fellow, Institute of Zoology, Chinese Academy of Sciences
Develops AI-enabled single-cell and spatial omics toolkits to track molecular dynamics from health to disease, with first-author papers in Cell and Nature Methods.
Focus: Single-cell analytics · Spatial omics AI
Professor, CUHK
Leads gut microbiome research for gastrointestinal cancers as Assistant Dean of CUHK’s Faculty of Medicine.
Keynote: Gut Microbiome/Metabolites in MASLD and HCC via Gut-Liver Axis
Distinguished Chair Professor, UT Dallas
Computational genomics pioneer whose tools reshaped transcriptome and epigenome analysis.
Keynote: Adeno-to-squamous transition drives resistance to KRAS inhibition
Professor, Emory University
Directs prostate & GU oncology research at Winship Cancer Institute, focusing on epigenetic regulatory networks.
Keynote: Systems biology approaches to deciphering prostate cancer regulation
Professor, Columbia University
Dissects chromatin regulatory networks and mutation-driven epigenetic vulnerabilities.
Keynote: Genetic Dissection of Chromatin Regulatory Network
Associate Professor, HKUST
Quantifies tumor immune “temperature” via spatial omics and advanced computation.
Keynote: Quantifying the immune temperature of cancer cells with spatial omics
Associate Professor, NTU
Explores 3D genome architecture and AI-assisted cancer vulnerabilities.
Keynote: AI × Cancer Biology: Harnessing Big Data to Decode 3D Genome Architecture
Associate Professor, OHSU
Builds computational resources to interrogate tumor metabolic reprogramming.
Keynote: Advancing computational tools to study metabolic reprogramming
Researcher, HKUST
Investigates phase separation biology and neural systems with publications in Cell and Science.
Keynote: Percolation and its function in biological systems
Dean, School of Translational Medicine, Soochow University
European Academy of Sciences member with 300+ papers on MSC immunology and inflammatory tumor microenvironments.
Keynote: Mesenchymal Stem Cells and Inflammatory Tumor Environment
Dean, Institute of Translational Medicine, Zhejiang University
AAAS Fellow and metabolism pioneer revealing signaling–metabolism coupling.
Keynote: Metabolic Regulation of Cancer and Immunity
Chair Professor, Shanghai Jiao Tong University
Applies complex networks and AI to systems biology with 28,000+ citations.
Keynote: Dynamical Systems Biology with AI
Professor, Peking University
Formulated the “cross-kingdom regulation of metabolic homeostasis” concept with high-impact publications in Science, Cell and Nature.
Keynote: Cross-kingdom regulation of host metabolic homeostasis
Chair Professor, SUSTech School of Medicine
ICSB co-founder and AAAS/IEEE Fellow who advances cancer informatics across biological big data, tumor immunology, and cerebrovascular metabolism.
Keynote: Chemical homeostasis imbalance/rebalance insights into Alzheimer’s
Dean, School of Public Health, Zhejiang University
Leads research on iron metabolism, ferroptosis, and trace element homeostasis, driving “iron science” toward clinical translation.
Keynote: Ferroptosis, iron science, and therapies for major diseases
President, Peking University Sixth Hospital
Integrates multi-omics and digital psychiatry to decode mental-disorder susceptibility and build personalized intervention models.
Keynote: Multi-omics pathogenesis and translational psychiatry
Professor, College of Chemistry, Peking University
Explores 3D chromatin organization and tumor gene regulation, known for discovering the “magic number effect” in hydrated ion transport.
Keynote: 3-D chromatin structure, methylation and gene expression in cancer
Professor, School of Medicine, Westlake University
Proposed the “Oncorganology” paradigm to interpret lung cancer evolution, covering driver genes, transdifferentiation, and therapy resistance.
Keynote: To Be or Not to Be — The Existentialism of PIK3CA Mutation
Assistant Professor, PKU International Cancer Institute
Applies AI and computational biology to aging and metabolic diseases, publishing in Nature Biotechnology, Cell, and Aging Cell.
Keynote: Revolutionizing target discovery for complex diseases
Associate Professor, Dept. of Automation, Tsinghua University
Pioneers mesoscale intravital imaging and digital adaptive optics to boost throughput and spatiotemporal resolution.
Keynote: Mesoscale intravital fluorescence microscopy
Venue: Shenzhen DoubleTree by Hilton Hotel, 3F, Bolin Hall A
| Time | Topic | Speaker & Affiliation |
|---|---|---|
| 08:30-08:40 | Opening Host: Jing Li | |
| Group Photo | ||
| Chair: Xuerui Yang | ||
| 08:40-08:55 | Single-cell lineage tracing and tumor evolution analysis | Zheng Hu (Shenzhen Institute of Advanced Technology, CAS) |
| 08:55-09:10 | Spatiotemporal evolution and precision treatment of malignant tumors | Lei Chen (Eastern Hepatobiliary Surgery Hospital) |
| 09:10-09:25 | Role of novel multispecific antibodies in tumor immunotherapy | Fan Yang (Renji Hospital, Shanghai Jiao Tong University) |
| Chair: Renchu Guan | ||
| 09:25-09:40 | Mechanism analysis of tumor immunotherapy resistance and exploration of combination therapy strategies | Yongsheng Li (Harbin Medical University) |
| 09:40-09:55 | Beyond the Hype: A Critical Look of the Dazzling Spatial omics | Gang Cao (Shenzhen Institute of Technology) |
| Chair: Huiyan Sun | ||
| 09:55-10:10 | A System Perspective on the Sperm RNA Code of Aging | Junchao Shi (Beijing Institute of Genomics, CAS) |
| 10:10-10:25 | Chronic disease risk analysis and precision nutrition exploration | Gengjie Jia (Agricultural Genomics Institute, CAAS) |
| Chair: Xiaopei Shen | ||
| 10:25-10:40 | Single-cell spatial omics mining technology | Ruiqiao He (Institute of Zoology, CAS) |
| 10:40-10:50 | Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in Pancreatic Cancer | Minmin Chen (Shenzhen Bay Laboratory) |
| 10:50-11:05 | New Technology Development and Application Translation for Synthetic Biology and Genomics | Maohua Zhang (Boke Biotech Co., Ltd.) |
| 11:30-13:00 | Lunch | |
Venue: Shenzhen DoubleTree by Hilton Hotel, 3F, Bolin Hall A
| Time | Topic | Speaker & Affiliation |
|---|---|---|
| Opening Host: Jun Tian | ||
| 13:30-13:55 | Clinical omics analysis and AI-driven antibody drug discovery | Zhiwei Cao (Fudan University) |
| 13:55-14:20 | Cross-scale integration model and mechanism exploration of cellular and molecular processes under spatial resolution | Xuerui Yang (Tsinghua University) |
| Chair: Haixia Guo | ||
| 14:20-14:35 | Evolution analysis and therapeutic drug screening of esophageal adenocarcinoma based on precancerous stem cells | Shan Wang (Zhejiang University) |
| 14:35-14:50 | Tracing unknown tumor origins with a biological pathway-based transformer model | Mengsha Tong (Xiamen University) |
| Chair: Yuanjie Li | ||
| 14:50-15:05 | Bladder cancer plasticity intervention strategy research | Yuqing Li (Huanan Hospital, Shenzhen University) |
| 15:05-15:20 | Multi-omics study of adamantinomatous craniopharyngioma | Xianlong Wang (Fujian Medical University) |
| Chair: Huiyan Sun | ||
| 15:30-15:45 | LINC02593: A Potential Glioma Suppressor via TNFα/NF-κB Pathway | Yifeng Yang (ShanghaiTech University) |
| 15:45-16:00 | Transcriptional regulation in immune system based on 3D genome research | Shaoqi Zhu (Sun Yat-sen University) |
| Chair: Zhenyu Huang | ||
| 16:00-16:15 | Application of interpretable AI based on large language models in synthetic lethality anticancer drug target discovery | Jie Zheng (ShanghaiTech University) |
| 16:15-16:30 | Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer | Wenhao Shi (Tsinghua University) |
| Chair: Xuechen Mu | ||
| 16:30-16:45 | SP1 Binding Shapes Local Mutation Rates in Cancer Genomes through Impaired DNA Repair | Hu Fang (Huanan Hospital, Shenzhen University) |
| 16:45-17:00 | RPcontact: A language model-based method for RNA–Protein contact prediction from sequence | Jiuhong Jiang (Guangzhou Laboratory) |
Venue: Shenzhen DoubleTree by Hilton Hotel, 3F, Hanlin Hall
| Time | Content | Speaker |
|---|---|---|
| Conference Chair: Ying Xu (Southern University of Science and Technology) | ||
| Opening Ceremony Host: Zhiwei Cao | ||
| 8:30-8:40 | Opening Remarks | Zhirong Sun (Tsinghua University) |
| 8:40-8:50 | Opening Remarks | Ying Xu (Southern University of Science and Technology) |
| 8:50-9:00 | Group Photo | |
| Chair: Weidong Tian | ||
| 9:00-9:50 | Metabolic Regulation of Cancer and Immunity | Zhimin Lu (Zhejiang University) |
| 9:50-10:40 | Genetic Dissection of Chromatin Regulatory Network | Chao Lu (Columbia University) (Online) |
| Chair: Guoqing Liu | ||
| 10:50-11:40 | Mesenchymal Stem Cells and Inflammatory Tumor Environment | Yufang Shi (Soochow University) (Online) |
| 11:40-12:30 | Quantifying the immune temperature of cancer cells with spatial omics | Jiguang Wang (Hong Kong University of Science and Technology) |
| 12:30-14:00 | Lunch | |
Venue: Shenzhen DoubleTree by Hilton Hotel, 3F, Hanlin Hall
| Time | Content | Speaker |
|---|---|---|
| Chair: Chunman Zuo | ||
| 14:00-14:50 | To Be or Not to Be — The Existentialism of PIK3CA Mutation in Lung Cancer | Hongbin Ji (Westlake University) |
| 14:50-15:40 | Ferroptosis, Iron Science and Diagnosis/Treatment of Major Diseases | Fudi Wang (Zhejiang University) |
| Chair: Yan Wang | ||
| 15:40-16:30 | Chemical Homeostasis Imbalance/Rebalance Insights into Alzheimer's Disease Associated with Cerebrovascular Diseases | Ying Xu (Southern University of Science and Technology) |
| 16:45-17:35 | 3-D chromatin structure, methylation and gene expression correlation in cancer cells | Yiqin Gao (Peking University) |
| 18:00-20:00 | Conference Banquet | |
Venue: Shenzhen DoubleTree by Hilton Hotel, 3F, Hanlin Hall
| Time | Content | Speaker |
|---|---|---|
| Chair: Youqiong Ye | ||
| 8:00-8:50 | Gut Microbiome/Metabolites in MASLD and HCC via Gut-Liver Axis | Jun Yu (The Chinese University of Hong Kong) |
| 8:50-9:40 | Exploring the pathogenesis and translational applications of common mental disorders based on multi-omics data | Weihua Yue (Peking University) |
| 9:40-10:30 | AI × Cancer Biology: Harnessing Big Data to Decode 3D Genome Architecture and Therapeutic Vulnerabilities | Melissa J. Fullwood (Nanyang Technological University) |
| Chair: Luqiang Zhang | ||
| 10:40-11:30 | Systems biology approaches to deciphering prostate cancer regulation | Jindan Yu (Emory University) |
| 11:30-12:20 | Advancing computational tools and resources to study metabolic reprogramming in cancer | Chi Zhang (Oregon Health & Science University) |
| 12:20-13:20 | Lunch | |
Venue: Shenzhen DoubleTree by Hilton Hotel, 3F, Hanlin Hall
| Time | Content | Speaker |
|---|---|---|
| Chair: Fuyi Xu | ||
| 13:20-14:10 | Mesoscale intravital fluorescence microscopy | Jiamin Wu (Tsinghua University) |
| 14:10-15:00 | Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer | Micheal Zhang (University of Texas at Dallas) (Online) |
| 15:00-15:50 | Revolutionizing Target Discovery for Complex Diseases: A Deep Learning-Driven Approach | Zhengwei Xie (Peking University) |
| Chair: Fengbiao Guo | ||
| 15:50-16:40 | Cross-kingdom regulation of host metabolic homeostasis by gut microbial enzymes and metabolites | Changtao Jiang (Peking University) (Online) |
| 16:40-17:30 | Percolation and its function in biological systems | Zeyu Shen (Hong Kong University of Science and Technology) |
| 17:30-18:20 | Dynamical Systems Biology with AI | Luonan Chen (Shanghai Jiao Tong University) |
| Category | Participant | Fee (RMB) |
|---|---|---|
| DragonStar Course | All attendees | 500 / person |
| Young & Expert Forum + International Symposium | Professional delegate | 1500 (before Nov 15) /2000 (after Nov 15) |
| Student delegate | 1200 (before Nov 15) /1500 (after Nov 15) |
Upload your talk title and abstract via this channel.
Register for the 2–4 December DragonStar training sessions.
Complete your 5–7 December Young Forum & ICSB registration.
Reference: ICSB 2025 + Your Name when submitting payment.
Contact: Ms. Tongmei Lu
Phone: +86-147-0445-5433
Email: lutm@mail.sustech.edu.cn
Use this channel for registration links, invoices, invitation letters, visa materials, and DragonStar/Forum arrangements.
Account Name: Fujian Society for Bioinformatics
Account No.: 4100021709200021073
Bank: Industrial and Commercial Bank of China, Xiamen University Branch
Memo: 2025 14th International Symposium on Cancer Systems Biology + Name
Bank transfer and QR payments are both accepted; scan the payment QR code above or contact Ms. Tongmei Lu (+86-14704455433) for assistance.
Agenda attachments and full speaker lists are available through the registration QR links. Reach out to Ms. Tongmei Lu for any registration support.
Sponsorship application deadline: 15 November 2025 (limited slots, first-come-first-served). Contact Ms. Tongmei Lu at +86-147-0445-5433 for tailored collaboration plans.
Confirmed partners: BOKE, Illumina, GENEWIZ, 01Life. Biomedical, instrumentation, publishing, and technology service organizations are welcome to participate.
From fundamental discovery to clinical translation, ICSB 2025 welcomes global researchers and partners to explore new precision-medicine paradigms together in Shenzhen.